The human-derived novel gut commensal <i>Luoshenia tenuis</i> regulates body weight and food intake in mice

Many studies have revealed that gut microbes modulate host metabolism. In this study, we characterized the therapeutic effects of a novel commensal Luoshenia tenuis against metabolic disorders. First, by in silico analysis, demonstrated was prevalent in microbiomes healthy humans but were depleted specifically obesity cohorts. Further vitro cultivation L. produced short chain fatty acids (SCFAs) verified to metabolism and some other volatile metabolites benefit hosts anti-inflammation anti-tumor. Second, gavage significantly decreased body weight gain food intake high-fat diet (HFD)-feeding C57BL/6J mice, which parallel with changed expression level genes related satiety feeding behavior. We then performed trial using induced obese (DIO) it administration alleviated abnormal glucose lipid metabolisms reduced inflammatory response. summary, study previously-unknown human microbe benefited metabolism, set stage for development next-generation probiotic applicable treatment